NHẬN XÉT NỒNG ĐỘ AFP, AFP-L3, PIVKA II VÀ ĐẶC ĐIỂM SIÊU ÂM Ổ BỤNG Ở BỆNH NHÂN VIÊM GAN B TẠI BỆNH VIỆN BẠCH MAI

Abstract

Aim: commenting on the concentration of AFP, AFP-L3, PIVKA II and characteristics of abdominal ultrasound in hepatitis B patients at Bach Mai hospital. Patients and methods: Prospective study of 311 hepatitis B patients from October 2019 to March 2021. Results: The most common age group was 41-70 years old (68, 5%). The average age was 48.7±12.3 years old, the disease was more common in men than women (2.5 times). The most common clinical symptoms include: Anorexia (25.7%), fatigue (32.5%), right lower quadrant abdominal pain (16.7%), abdominal distension (16.7%), jaundice (17.4%). 77.5% of patients did not have cirrhosis, and 22.5% of patients had cirrhosis. 2,3% of patients had both hepatitis B and C. Median of AFP, AFP-L3, PIVKA in the elevated group are 17.2 ng/mL; 9.4%; 24.0 mAU/mL, respectively. 23 patients had liver tumors (7.4%) of which 78.3% of tumors are less than 3 cm. All tumor lesions are benign. Conclusion: AFP, AFP-L3, PIVKA levels can be increased in hepatitis B with/without cirrhosis but not high. In this group, we should follow up regularly to detect liver cancer.