ROLE OF CT PERFUSION IN EVALUATING THE EFFECTIVENESS OF BYPASS SURGERY IN THE TREATMENT OF MOYAMOYA DISEASE
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Abstract
Objective: The study aims to evaluate the role of CT perfusion in assessing the effectiveness of bypass surgery in the treatment of Moyamoya disease. Patients and Methods: The study group consisted of 27 patients diagnosed with Moyamoya disease based on clinical evaluation, CT, and/or MRI. All patients underwent CT perfusion imaging before surgery and one month after surgery between May 2021 and March 2025. Preoperative and postoperative CT perfusion imaging data were collected retrospectively. The effectiveness of arterial bypass surgery was assessed based on preoperative and postoperative CT perfusion imaging results, focusing on changes in cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) in the ischemic hemisphere, clinical symptom improvement was evaluated using the modified Rankin Scale (mRS). Results: Statistically significant differences were observed in quantitative CBV, CBF, MTT, and TTP values (P<0.05) in the ischemic hemisphere, as well as in the relative parameters rCBV, rCBF, rMTT, and rTTP (P<0.05) between the ischemic and contralateral hemispheres, when comparing preoperative and 6-month postoperative time points following STA–MCA bypass surgery in all Moyamoya patients (n=27). Conclusions: CT perfusion is valuable in assessing the effectiveness of bypass surgery in the treatment of Moyamoya disease. The MTT map and TTP map have the capability of being quite sensitive to the presence of altered brain perfusion at early time.
Keywords
Moyamoya disease, CT persusion, modified Rankin Scale (mRS)
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References
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