MỐI LIÊN QUAN GIỮA EBV-DNA VÀ UNG THƯ VÒM MŨI HỌNG

Abstract

Objectives: Evaluate the correlation between plasma EBV-DNA levels and clinical, paraclinical characteristics, as well as disease stages in patients with nasopharyngeal carcinoma. Subjects: 119 patients diagnosed and treated for nasopharyngeal carcinoma at K Hospital and the Center for Genomics and Proteomics of Hanoi Medical University from 2013 to 2016. Methods: A cross-sectional study utilizing quantitative measurement of plasma EBV-DNA levels through realtime PCR before and after treatment, combined with an analysis of clinical and paraclinical characteristics. Results: Before treatment, 74.0% of patients had EBV-DNA levels ≥ 300 copies/mL, which decreased to 16.8% after treatment (p<0.01). EBV-DNA levels were significantly associated with cervical lymph node size, TNM staging, and treatment response prognosis. Patients in stages III-IV had a significantly higher likelihood of maintaining elevated EBV-DNA levels compared to those in stages I-II. Conclusion: Plasma EBV-DNA levels are an important biomarker for screening, diagnosing, and monitoring treatment for nasopharyngeal carcinoma. The study results provide a scientific basis for improving early detection and treatment effectiveness for nasopharyngeal carcinoma in clinical practice.