MỐI LIÊN QUAN GIỮA MỨC ĐỘ LO ÂU, TRẦM CẢM, STRESS VÀ CÁC CHỈ SỐ T3, FT4, TSH, TRAB TRÊN BỆNH NHÂN BASEDOW ĐIỀU TRỊ TẠI BỆNH VIỆN NỘI TIẾT TRUNG ƯƠNG

Abstract

Objective: To determine the relationship between T3, FT4, TSH, TRAb and levels of anxiety, depression, stress in Basedow patients. Methodology: Cross-sectional descriptive study with analysis on 351 patients diagnosed with Basedow. Biochemical indices T3, FT4, TSH, TRAb were quantified. Anxiety, depression, and stress levels were assessed using the DASS-21 scale. Multivariable logistic regression analysis was used to identify independent factors associated with psychological disorders. Logistic regression models were applied to three different sample groups: n=351 (only FT4 and TSH available); n=244 (missing T3) and n=164 (complete data on T3, FT4, TSH, TRAb). Results: In the N=164 group, TRAb was significantly associated with the risk of stress (p=0.015, OR=1.041) and depression (p=0.014, OR=1.041). FT4, TSH, and T3 were not significantly associated with anxiety or stress. In the N=244 group, TRAb continued to show a trend of association with anxiety and depression, though statistical significance was not reached. In the N=351 group, FT4 showed a significant association with the risk of anxiety and stress, suggesting that FT4 may be a weak predictor, detectable only with a larger sample size. Conclusion: TRAb appears to be the most consistently associated factor with the risk of stress and depression across regression models. FT4 may have predictive value for anxiety and stress, but larger studies are needed to confirm its role. Thyroid hormone indices could serve as potential markers for psychological risk screening in Basedow patients and should be considered in comprehensive clinical assessments.