LIÊN QUAN GIỮA ĐA HÌNH RS2383207 GEN CDKN2B – AS1 VÀ TỔN THƯƠNG ĐỘNG MẠCH VÀNH Ở BỆNH NHÂN HỘI CHỨNG ĐỘNG VÀNH MẠN TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2023 – 2025

Abstract

Background: The rs2383207 polymorphism of the CDKN2B–AS1 gene has been shown to be associated with coronary artery disease by influencing atherosclerosis, and may also be related to the severity of coronary artery lesions. Objectives: To investigate the association between the rs2383207 polymorphism of the CDKN2B–AS1 gene and coronary artery lesions in patients with chronic coronary syndrome at Can Tho University of Medicine and Pharmacy Hospital. Materials and methods: A cross-sectional descriptive study was conducted from 2023 to 2025 on patients diagnosed with chronic coronary syndrome who met the inclusion criteria. All patients underwent percutaneous coronary angiography and 2 mL of peripheral blood was collected for genotyping using real-time PCR. Significant coronary artery stenosis was defined as > 50%, and severe stenosis as > 70%. Coronary artery stenosis is classified into five categories: normal, non-significant stenosis (0–50%), moderate stenosis (50–70%), severe stenosis (70–90%), and critical stenosis or near-total occlusion (>90%). The rs2383207 genotypes of the CDKN2B–AS1 gene included GG, GA, and AA. Results: A total of 69 patients were enrolled in the study. The distribution and frequency of rs2383207 polymorphism in the CDKN2B–AS1 gene were as follows: the GG genotype was found in 39 cases (56,5%), GA genotype in 25 cases (36,2%), and AA genotype in 5 cases (7,2%). A significant association was observed between rs2383207 genotypes and the degree of left anterior descending (LAD) artery stenosis (p < 0,001), as well as with clinically significant LAD stenosis (p < 0,001). Additionally, analysis of the combined GG + GA genotype model revealed associations with LAD stenosis severity (p < 0,001), clinically significant LAD stenosis (p < 0,001), and severe LAD stenosis (p = 0,043). Furthermore, the rs2383207 genotype and the GG + GA model were significantly associated with the presence of significant stenosis in ≥ 2 coronary arteries (p = 0,011 and p = 0,005, respectively). Conclusion: The frequencies of the GG, GA, and AA genotypes were 56,5%, 36,2%, and 7,2%, respectively. There was an association between the rs2383207 polymorphism of the CDKN2B–AS1 gene and the combined GG + GA genotype model with the degree of left anterior descending artery stenosis, clinically significant LAD stenosis, as well as significant stenosis in two or more coronary arteries. Additionally, the GG + GA genotype model was associated with severe LAD artery stenosis.