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PLASMA URIC ACID CONCENTRATION AND RELATED FACTORS IN CHRONIC KIDNEY DISEASE PATIENTS AT THAI BINH PROVINCIAL GENERAL HOSPITAL
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Abstract
Objectives: To investigate plasma uric acid concentration and some related factors in patients with chronic kidney disease at Thai Binh Provincial General Hospital. Subjects and Methods: A descriptive cross-sectional study was conducted to collect data on plasma uric acid concentration, the prevalence of hyperuricemia, and some related factors in 90 patients diagnosed with chronic kidney disease treated at the Department of Nephrology – Musculoskeletal, Thai Binh Provincial General Hospital, from October 2024 to December 2024. Results: The average plasma uric acid concentration of the study subjects was 500.8 ± 142.7 µmol/L. The prevalence of hyperuricemia was 78.9%. The rate of hyperuricemia increased with the stage of chronic kidney disease, which was statistically significant with p < 0.05. There was a correlation between the prevalence of hyperuricemia and co-occurring dyslipidemia in chronic kidney disease patients with p < 0.05. Plasma uric acid concentration had a positive correlation with blood urea concentration, r = 0.251, p = 0.017. Conclusion: There is a relationship between plasma uric acid concentration and the stages of chronic kidney disease, dyslipidemia, and plasma urea concentration in patients with chronic kidney disease.
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Keywords
Uric acid, chronic kidney disease
References
2. Johnson RJ, Sanchez Lozada LG, Lanaspa MA, et al. (2023). Uric Acid and Chronic Kidney Disease: Still More to Do. Kidney International Report, 8(2), 229-239. DOI: https://doi.org/ 10.1016/j.ekir.2022.11.016
3. Gherghina M. E., Peride I., Tiglis M. et al. (2022). Uric Acid and Oxidative Stress-Relationship with Cardiovascular, Metabolic, and Renal Impairment. Int J Mol Sci, 23(6). DOI: https://doi.org/10.3390/ijms23063188
4. Bùi Thị Hồng Châu, Lê Thị Xuân Thảo, Nguyễn Đăng Khoa và cộng sự. (2024). Nồng độ acid uric huyết thanh và một số bệnh mạn tính ở người bệnh thận mạn. Tạp chí y học Việt Nam. Tháng 12, số 2(2), tr. 304-309.
5. KDIGO (2012). KDIGO 2012 Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney International suppements, 3(1), 5-14.
6. Annual Data Report (2014). CKD in the United States: An Overview of the USRDS Annual Data Report.
7. Huỳnh Thị Ngọc Ánh, Lê Thị Thuý, Hồ Thị Tuyết Thu và cộng sự. (2021). Nồng độ acid uric máu trên bệnh nhân bị bệnh thận mạn tại bệnh viện C thành phố Đà Nẵng. Tạp chí y học Việt Nam, 509(2), tr. 242-246.
8. Markus P Schneider, Karl F Hilgers, Matthias Schmid et al. (2018). Blood pressure control in chronic kidney disease: A cross-sectional analysis from the German Chronic Kidney Disease (GCKD) study. PLoS One, 13(8). DOI: https://doi.org/ 10.1371/journal.pone.0202604
9. Lê Hạnh Nguyên, Đỗ Gia Tuyển, Đặng Thị Việt Hà và cộng sự. (2023). Đánh giá rối loạn nồng độ acid uric máu ở bệnh nhân bệnh thận mạn chưa điều trị thay thế tại Bệnh viện đa khoa tỉnh Thanh Hoá. Tạp chí y học Việt Nam, 523(1), tr. 134-139.
10. Ala’a Alkerwi, Nicolas Sauvageot, Illiasse El Bahi et al. (2017). Prevalence and related risk factors of chronic kidney disease among adults in Luxembourg: evidence from the observation of cardiovascular risk factors (ORISCAV-LUX) study. BMC Nephrol, 18(1). DOI: https://doi.org/ 10.1186/s12882-017-0772-6