BIẾN CHỨNG GIÃN NÃO THẤT Ở BỆNH NHÂN LAO MÀNG NÃO ĐIỀU TRỊ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

Objectives: Hydrocephalus is one of the most common and severe neurological complications of tuberculous meningitis (TBM), playing a crucial role in determining patient prognosis and outcome. To describe hydrocephalus complications and associated risk factors in TBM patients treated at the National Hospital for Tropical Diseases. Methods: A retrospective study was conducted to analyze the incidence of complications and risk factors for hydrocephalus in TBM patients. Results: The incidence of hydrocephalus in tuberculous meningitis patients was 31.1%. Coma was observed significantly more frequently in the hydrocephalus group compared to the non-hydrocephalus group (64.3% vs. 16.1%, p = 0.001). Cerebrospinal fluid (CSF) xanthochromia and elevated CSF protein levels were also significantly higher in the hydrocephalus group than in the non-hydrocephalus group, at 38.5% vs. 16.1% (p = 0.048) and 2.04 g/L vs. 1.37 g/L (p < 0.048), respectively. CSF xanthochromia was identified as a prognostic factor for hydrocephalus in TBM patients (OR = 3.9, p = 0.048). Conclusion: CSF xanthochromia and elevated CSF protein levels are significant prognostic indicators for hydrocephalus in TBM patients.