NHẬN XÉT KẾT QUẢ ĐIỀU TRỊ VIÊM GAN VI RÚT B MẠN SAU 10 NĂM THEO DÕI NGOẠI TRÚ TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG

Abstract

Objective: To evaluate the effectiveness of antiviral treatment after 10 years in chronic hepatitis B patients at the National Hospital for Tropical Diseases in Vietnam. Methods: A retrospective descriptive study on 1,914 outpatients treated from December 2009 to December 2020. Results: Males comprised 59.8% of patients, with a mean age of 43.18±13.7 years. HBeAg-negative patients represented 78.1%, and 69% already had cirrhosis at treatment initiation. After 10 years of treatment, HBsAg clearance rates were 9.5% in non-cirrhotic patients versus 2.9% in cirrhotic patients (p<0.001). No mortality occurred in the non-cirrhotic group, while the cirrhotic group had a 15.8% mortality rate. Despite regular surveillance, only 18.5% of hepatocellular carcinoma cases were detected at an early stage. Conclusion: NA antiviral drugs are highly effective in controlling the virus and preventing complications. The HBsAg loss rate was 9.5% in the non-cirrhotic group, significantly higher than that in the cirrhotic group (2.9%). No mortality was recorded in the non-cirrhotic group, demonstrating the benefits of early detection and treatment.