KẾT QUẢ ĐIỀU TRỊ MÀY ĐAY MẠN TÍNH BẰNG KHÁNG HISTAMIN H1 LIỀU TĂNG DẦN TẠI MỘT SỐ CƠ SỞ Y TẾ TRÊN ĐỊA BÀN THÀNH PHỐ VINH

Abstract

A prospective study was conducted on 32 patients with chronic urticaria who sought consultation and treatment at Vinh Medical University Hospital and Nghe An General Friendship Hospital. The aim was to further evaluate the efficacy of stepwise up-dosing of H1-antihistamines in the management of chronic urticaria. The results showed that the mean scores for disease activity, frequency of symptom occurrence, and patients’ quality of life significantly improved after both standard-dose and up-dosed antihistamine treatment regimens, with p-values < 0.01 compared to baseline. Moreover, the mean disease control score significantly increased following the up-dosed regimen compared to the standard-dose treatment. The severity of the disease showed a progressive improvement after both standard and higher-dose treatment courses. No serious adverse events were reported. The incidence of adverse effects at the double-dose level was 9.4%, not significantly different from that at the standard dose. Reported adverse effects included headache (3.1%) and dry mouth (6.3%).