ẢNH HƯỞNG CỦA MỘT SỐ THUỐC CHỐNG VIÊM KHÔNG STEROID (CELECOXIB, ETORICOXIB, MELOXICAM) VỚI HUYẾT ÁP Ở BỆNH NHÂN THOÁI HÓA KHỚP NGUYÊN PHÁT

Abstract

Objectives: 1. To investigate the changes in blood pressure among patients with primary osteoarthritis received non-steroidal anti-inflammatory drugs (Celecoxib, Etoricoxib, or Meloxicam). 2. To evaluate certain factors associated with the impact of non-steroidal anti-inflammatory drugs on blood pressure in the study population. Background: Osteoarthritis commonly coexists with hypertension in the elderly. Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in osteoarthritis treatment but may influence on blood pressure. Study Population: The study included 183 patients diagnosed with osteoarthritis according to ACR criteria who were treated continuously for 2 weeks with one of the three NSAIDs mentioned above at Bach Mai Hospital and Hanoi Medical University Hospital from July 2024 to May 2025. Methods: This was a pre–post interventional study. Data on personal history, comorbidities, blood pressure, and VAS scores were collected at baseline (T0) and after 2 weeks of treatment (T1). Statistical analysis was performed using SPSS, with a significance level set at p < 0.05. Results: After 2 weeks, there was no statistically significant difference in systolic or diastolic blood pressure changes among the NSAID groups (p > 0.05). Blood pressure exceeding threshold occurred in 12.02% of patients. Patients with a history of hypertension had an 11.78 times higher risk of Blood pressure exceeding threshold compared to those without the previous history (p < 0.001).