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INVESTIGATION OF VITAMIN D LEVELS AND THE PREVALENCE OF HYPERTENSION AND CHRONIC KIDNEY DISEASE IN TYPE 2 DIABETES PATIENTS BY AGE AND GENDER
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Abstract
Background: Vitamin D plays an important role as a hormone, participating in supporting enzymatic, physiological, metabolic, and pathological processes related to many organs and systems of the human body. Some recent studies have shown a possible relationship between vitamin D deficiency and the onset and progression of type 2 diabetes. Therefore, a survey of vitamin D levels and the prevalence of common chronic diseases in type 2 diabetes patients by age group and gender is necessary to provide more important data for more effective prevention and treatment. Method: The study was conducted based on retrospectively available test data and medical records of type 2 diabetes patients who underwent outpatient examinations at Le Van Thinh hospital, Ho Chi Minh City, Vietnam and University Medical Center HCMC, Ho Chi Minh City, Vietnam, from January to May 2024. Results: the study included 273 patients with type 2 diabetes, most of whom were women. Results showed no difference in vitamin D levels by gender. Individuals aged 40 years and older had a higher rate of vitamin D deficiency (mild and severe) than those under 40. Furthermore, patients with chronic kidney disease exhibited a higher rate of mild and severe vitamin D deficiency compared to those with hypertension or dyslipidemia (p<0.001). Conclusion: The study found an association between age (40 years and older) and chronic kidney disease, along with vitamin D deficiency, in patients with type 2 diabetes. However, further studies are needed to better demonstrate the impact of vitamin D on type 2 diabetes.
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Keywords
vitamin D, diabetes, age, gender
References
2. Biswas T, Tran N, Thi My Hanh H, et al. Type 2 diabetes and hypertension in Vietnam: a systematic review and meta-analysis of studies between 2000 and 2020. BMJ Open, 2022, 12: e052725. doi: 10.1136/bmjopen-2021-052725.
3. Demay MB, Pittas AG; Bikle DD, et al. Vitamin D for the prevention of disease: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 2024, 109, 1907–1947.
4. Dominguez LJ, Veronese N, Marrone E, et al. Vitamin D and risk of incident type 2 diabetes in older adults: an updated systematic review and meta-analysis. Nutrients. 2024;16(11):1561. doi: 10.3390/nu16111561.
5. Enverga M, Isidro MJ, Ang-Golangco N. The association between serum 25-hydroxyvitamin D and glycemic control in patients with diabetes mellitus: a single-center retrospective study. J ASEAN Fed Endocr Soc. 2023; 38(1):13-20.
6. He J, Kang J, Mei Z, Zhou X, Yin Y and Zhu C. Gender-specific association between circulating 25-hydroxyvitamin D levels and diabetic retinopathy in patients with type 2 diabetes mellitus. Front. Endocrinol. 2025, 16:1541961. doi: 10.3389/fendo.2025.1541961.
7. Mangal DK, Shaikh N, Tolani H, et al. Burden of micronutrient deficiency among patients with type 2 diabetes: systematic review and meta-analysis. BMJ Nutrition, Prevention & Health. 2025, e000950. doi.org/10.1136/bmjnph-2024-000950.
8. Salih Y, Rassol M, Ahmed I, Mohammed A. Impact of vitamin D level on glycemic control in diabetes mellitus type 2 in Duhok. Ann Med Surg (Lond). 2021; 64:102208. https://doi.org/ 10.1016/j.amsu.2021.102208.
9. Thejeel SH, Jebur AS, & Barzan M. Vitamin D and its relationship to type 2 diabetes. Int. J. of Pharm. Sci, 2024, 2(5): 291-294.
10. Wang L, Liu X, Hou J, et al. Serum vitamin D affected type 2 diabetes though altering lipid profile and modified the effects of testosterone on diabetes status. Nutrients. 2020; 13(1):90.