Article Sidebar

pdf
Date Published: 29/09/2025
Abstract Views: 93
Views pdf: 53
DOI: https://doi.org/10.51298/vmj.v554i1.15557
Issue
Vol. 554 No. 1 (2025)
Section
Các bài báo
How to Cite
Nguyễn, V. M., Nguyễn, T. T., Trần, T. Ánh T., Đinh, T. G., Trần, T. L., Nguyễn, T. H. T., & Phạm, V. T. (2025). EVALUATION OF EARLY RESPONSE AND PROGNOSTIC FACTORS FOR TUMOR RESPONSE OF SUPERSELECTIVE TRANSARTERIAL CHEMOEMBOLIZATION WITH DC BEAD M1 IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA. Vietnam Medical Journal, 554(1). https://doi.org/10.51298/vmj.v554i1.15557

EVALUATION OF EARLY RESPONSE AND PROGNOSTIC FACTORS FOR TUMOR RESPONSE OF SUPERSELECTIVE TRANSARTERIAL CHEMOEMBOLIZATION WITH DC BEAD M1 IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA

Văn Mạnh Nguyễn, Tiến Thịnh Nguyễn, Thị Ánh Tuyết Trần, Trường Giang Đinh, Tùng Lâm Trần, Thị Huyền Trang Nguyễn, Văn Tuyền Phạm

Main Article Content

Abstract

Objective: To evaluate early response and prognostic factors of superselective DEB-TACE using DC Bead M1 in hepatocellular carcinoma (HCC). Methods: A prospective interventional clinical study was conducted on 35 patients with HCC (BCLC stage A, Child-Pugh class A, ECOG ≤ 2), treated at 108 Military Central Hospital from June 2024 to May 2025. Patients underwent superselective TACE with DC Bead M1 (70–150 µm) loaded with doxorubicin. Early response at 1-month post-intervention was assessed, including changes in tumor markers (AFP, PIVKA-II), tumor response according to mRECIST criteria, tumor necrosis rate, and analysis of factors associated with complete response. Results: Technical success 100%. Embolization at tumor-feeding artery (54.3%) and subsegmental artery (45.7%). Tumor size, AFP, PIVKA-II significantly decreased (p<0.05). Objective response rate was 100% (74.3% CR, 25.7% PR). In PR group, 88.9% had ≥50% tumor necrosis. Tumor size ≤ 3 cm (p=0.036) and single feeding artery (p=0.015) predicted complete response. Conclusion: Superselective transarterial chemoembolization using DC Bead M1 demonstrates a high early response rate in HCC, with the prospect of curative treatment. Tumor size ≤ 3 cm and a single feeding artery are favorable prognostic factors for complete response

Article Details

Keywords

Hepatocellular carcinoma, superselective TACE, DC Bead M1.

References

Kang Y. J., Lee B. C., Kim J. K., et al. (2020). Conventional Versus Small Doxorubicin-eluting Bead Transcatheter Arterial Chemoembolization for Treating Barcelona Clinic Liver Cancer Stage 0/A Hepatocellular Carcinoma. Cardiovasc Intervent Radiol, 43(1): 55-64.
2. Singal A. G., Llovet J. M., Yarchoan M., et al. (2023). AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology, 78(6): 1922-1965.
3. Ayyub J., Dabhi K. N., Gohil N. V., et al. (2023). Evaluation of the Safety and Efficacy of Conventional Transarterial Chemoembolization (cTACE) and Drug-Eluting Bead (DEB)-TACE in the Management of Unresectable Hepatocellular Carcinoma: A Systematic Review. Cureus, 15(7): e41943.
4. Yi J. W., Hong H. P., Kim M. S., et al. (2022). Comparison of Clinical Efficacy and Safety between 70-150 µm and 100-300 µm Doxorubicin Drug-Eluting Bead Transarterial Chemoembolization for Hepatocellular Carcinoma. Life (Basel), 12(2).
5. Yasuhiro U., Tsuyoshi T., Akihiro N., et al. (2016). Detecting hepatic nodules and identifying feeding arteries of hepatocellular carcinoma: efficacy of cone-beam computed tomography in transcatheter arterial chemoembolization. Hepatoma Research, 2: 231-236.
6. Takayasu K., Arii S., Kudo M., et al. (2012). Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines. J Hepatol, 56(4): 886-892.
7. Ngô Quốc Bộ, Nguyễn Trung Kiên, Đặng Đình Phúc, et al. (2022). Đánh giá kết quả bước đầu phương pháp nút mạch hóa chất siêu chọn lọc trong điều trị ung thư biểu mô tế bào gan tại bệnh viện K. Tạp chí Y học Việt Nam, 518(2).
8. Chen S. C., Ho H. L., Liu C. A., et al. (2025). PIVKA-II as a surrogate biomarker for therapeutic response in Non-AFP-secreting hepatocellular carcinoma. BMC Cancer, 25(1): 199.
9. Golfieri R., Cappelli A., Cucchetti A., et al. (2011). Efficacy of selective transarterial chemoembolization in inducing tumor necrosis in small (<5 cm) hepatocellular carcinomas. Hepatology, 53(5): 1580-1589.
10. Spreafico C., Cascella T., Facciorusso A., et al. (2015). Transarterial chemoembolization for hepatocellular carcinoma with a new generation of beads: clinical–radiological outcomes and safety profile. Cardiovasc Intervent Radiol, 38: 129-134.