ĐẶC ĐIỂM XÉT NGHIỆM HUYẾT HỌC VÀ MỘT SỐ YẾU TỐ LIÊN QUAN Ở NGƯỜI BỆNH U BUỒNG TRỨNG LÀNH TÍNH TRƯỚC PHẪU THUẬT TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG

Abstract

Objective: The study aimed to describe the characteristics of hematological tests and some related factors in patients with benign ovarian tumors before surgery at the Central Obstetrics Hospital from 2021 to 2023. Study design: Cross-sectional descriptive study. Results: In a total of 215 patients with benign ovarian cancer, the mean values ​​of indicators such as age, fibrinogen, CA-125, HE4 and ROMA test were all low, reflecting the biological characteristics of the non-malignant group. The risk of ovarian cancer increased significantly in the age group ≥ 60 with OR = 2.21 and p < 0.0001. In contrast, the age group 40–59 had a lower risk than <40 years old, showing that the variation with age was not completely linear. In addition, postmenopausal women had a nearly 3 times higher risk of cancer than premenopausal women, emphasizing the role of hormones in the pathogenesis. Factors such as age ≥ 40, CA-125 ≥ 31.36 U/mL, Fibrinogen ≥ 3.81 g/L and ROMA test ≥ 8.71 all increased the risk of ovarian cancer with high Odds Ratio and statistically significant p-value. In particular, CA-125 and ROMA test had ORs above 18, showing the ability to clearly distinguish between benign and cancerous tumors. All four indices Fibrinogen, CA-125, HE4 and ROMA test have quite good diagnostic value for ovarian cancer with high area under the ROC curve (AUC), in which CA-125 and ROMA test have AUC above 0.85, showing good ability to distinguish between benign and cancerous tumors. Fibrinogen, although an inflammatory index, also achieved AUC of approximately 0.78, showing potential to support diagnosis. Conclusion: The CA-125, ROMA test, age and fibrinogen indices have high prognostic value in distinguishing ovarian cancer.