Article Sidebar
Views pdf: 74
STUDY ON PERIPHERAL BLOOD NEUTROPHIL/LYMPHOCYTE RATIO (NLR) AND ITS RELATIONSHIP WITH SOME FACTORS IN PATIENTS AFTER KIDNEY TRANSPLANTATION
Main Article Content
Abstract
Objective: Study on the Neutrophil/Lymphocyte ratio (NLR) and its relationship with some factors in patients after kidney transplantation. Subjects and methods: 120 post-transplant patients were monitored and treated at the Department of Nephrology - Dialysis, 108 Military Central Hospital and 30 healthy people of similar age and gender. The study was conducted from September 2024 to May 2025. Results: The mean age of the study group was 43 years; 75.8% of patients were male. The median value of the NLR ratio of the post-transplant patient group was 1.96, which was significantly higher than that of the control group at 1.61 (p < 0.05). The rates of increased NLR and no increased NLR after transplantation were similar. The NLR ratio was significantly associated with prolonged dialysis time before transplantation and was weakly correlated with CRP (p < 0.05), suggesting the role of NLR as a marker of systemic inflammation. However, NLR was not significantly associated with age, sex, anemia, BMI, dyslipidemia, hepatitis B/C virus infection, or renal function. Conclusion: The median NLR in patients after kidney transplantation was higher than in the control group. Longer pretransplant dialysis time and serum CRP were associated with increased NLR in patients after kidney transplantation. NLR may be an effective marker for identifying subclinical inflammation.
Article Details
Keywords
Neutrophil/Lymphocyte Ratio; kidney transplantation.
References
2. Haller M., Gutjahr G., Kramar R., et al (2011). Cost-effectiveness analysis of renal replacement therapy in Austria. Nephrology Dialysis Transplantation, Volume 26, Issue 9, September 2011, Pages 2988–2995.
3. Hogendorf P., Suska A., Skulimowski A., et al. (2018). Neutrophil-lymphocyte ratio and creatinine reduction ratio predict good early graft function among adult cadaveric donor renal transplant recipients. Single institution series. Pol Przegl Chir 2018; 90: 28-33.
4. Netto M. C., Alves-Filho G., Mazzali M. (2012). Nutritional status and body composition in patients early after renal transplantation. Transplant Proc, 44(8): 2366-8.
5. Kiên Trương Quý (2023). Nghiên cứu đặc điểm nhiễm, kiểu gen virus BK và đánh giá kết quả điều trị người bệnh sau ghép thận nhiễm virus BK. Học viện Quân y, Luận án tiến sĩ y học.
6. Nguyễn Trung Kiên, Tạ Việt Hưng, Nguyễn Hà Thanh (2022). Đặc điểm một số chỉ số tế bào máu ngoại vi ở bệnh nhân lọc máu chu kỳ tại Bệnh viện Quân y 103. Tạp chí Y Dược học Quân sự, 8: 24-32.
7. Thư Hoàng Thị Anh và cộng sự (2023). Nghiên cứu tỷ lệ bạch cầu đoạn trung tính trên tế bào lympho (NLR) và tỷ lệ giữa tiểu cầu trên lympho (PLR) ở bệnh nhân lupus ban đỏ hệ thống tại Bệnh viện Trường Đại học Y - Dược Huế. Tạp chí Y Dược học - Trường Đại học Y Dược Huế, 3: 158-163.
8. Giray E., Muge D., Burak K., et al. (2019). High neutrophil-to-lymphocyte ratio predicts acute allograft rejection in kidney transplantation: retrospective study. Turk J Med Sci, 49: 525-530
9. Turkmen K., Guney I., Yerlikaya F. H., et al. (2012). The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail, 34(2): 155-9.
10. Mario N., Akanksha A., Abhinav G. et al. (2018). Neutrophil-to Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio Predict Acute Cellular Rejection in the Kidney Allograft. Ann Transplant; 23: 467-474.