KẾT QUẢ ĐIỀU TRỊ BẢO TỒN NHÃN CẦU TRÊN BỆNH NHÂN U NGUYÊN BÀO VÕNG MẠC

Abstract

Objective: To evaluate the results of conservative treatment of retinoblastoma (RB) at VietNam National Eye Hospital from 2015 to December 2018. Subjects and methods: Non-controlled clinical intervention study on 48 eyes of 43 RB patients who had been treated salvage global with an average follow-up time of 22.1 ± 10.7 months. Results: The average age of the study group of patients was 15.7 ± 12.8 months. There was no difference in the ratio of male and female children. 35/43 patients (81.4%) were diagnosed through screening due to a history of 1 eye diagnosed with RB, 6 patients (13.9%) were detected with leukocoria and 2 patients (4.7%) strabismus. The results of conservative treatment were 35/48 eyes (72.9%) successfully treated, of which 100% of group A (6/6 eyes), 90.9% of group B (20/22 eyes), 66.7% of group C (4/6 eyes), 50% of group D (4/8 eyes) and the lowest was 16.7% of group E (1/6 eyes). There were 13 eyes (27.1%) that failed treatment and required enucleation (due to treatment failure including progressive tumor, vitreous seeding or vitreous hemorrhage). After treatment, 12/35 eyes of children under 36 months did not cooperate in visual acuity testing but 100% had results of fixation. There were 15/23 eyes had visual acuity of 20/200 or better, with 4 eyes achieving visual acuity of 20/20 ( Snellen VA test). Conclusion: The success rate of eye conservation treatment in RB is multidisciplinary coordination. The prognosis of visual acuity after conservative treatment is related to the location and size of the tumor.