ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG Ở TRẺ EM NHIỄM ADENOVIRUS NẶNG, NGUY KỊCH

Abstract

Objective: To describe the clinical and paraclinical characteristics of children with severe and critical Adenovirus infection at Vietnam National Children's Hospital. Subjects and Methods: A retrospective cross-sectional study was conducted on 372 children under 17 years old diagnosed with severe or critical Adenovirus infection and treated at Vietnam National Children's Hospital from July 2022 to July 2023. Results: Children aged 12–60 months accounted for the highest proportion (56.5%), with most cases occurring in the autumn–winter season. Children with underlying conditions such as malnutrition, neuromuscular diseases, and chronic lung disease tended to have more severe progression. Common symptoms included upper respiratory tract inflammation (92.7%), fever ≥ 39°C (62.3%), and diarrhea (44.1%). Frequent complications were PIBO (9.4%), multiple organ failure (8.9%), and ARDS (7.8%). Common paraclinical abnormalities included elevated CRP, ferritin, LDH, D-dimer, and reduced CD3, CD4, and CD8 counts. Chest X-ray findings mainly showed infiltrates and diffuse opacities. Conclusion: Severe and critical Adenovirus infections often affect young children with diverse clinical presentations and a high risk of complications, especially in those with underlying diseases, malnutrition, or cellular immune dysfunction. Early recognition and timely intervention are key factors in improving prognosis.