ĐÁNH GIÁ HIỆU QUẢ MIFEPRISTONE PHỐI HỢP MISOPROSTOL TRONG ĐÌNH CHỈ THAI TỪ 13 ĐẾN 22 TUẦN TUỔI Ở NHÓM VỊ THÀNH NIÊN TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG

Abstract

Objective: To evaluate the effectiveness and safety of the combined Mifepristone–Misoprostol regimen for medical termination of pregnancy between 13 and 22 weeks of gestation in adolescents. Subjects and Methods: This retrospective cross-sectional study was conducted on 83 adolescent pregnant patients (aged 10–18 years) with pregnancies from 13 to 22 weeks, who underwent medical abortion using the Mifepristone–Misoprostol regimen at the National Hospital of Obstetrics and Gynecology from January 2021 to May 2024. Results: The mean age was 16.3 ± 1.6 years, and the mean gestational age was 17.5 ± 3.1 weeks. The abortion success rate was 100%. The average dose of Misoprostol was 700 ± 302 mcg, and the mean expulsion time was 10.2 ± 7.1 hours. A total of 29 cases (34.9%) required post-abortion uterine intervention, mainly due to retained placenta or prolonged bleeding. Adverse effects occurred in 13.3% of cases, most commonly mild fever (9.6%) and nausea (3.6%). Higher gestational age was significantly associated with higher Misoprostol dose and longer expulsion time (p < 0.05). Conclusion: The Mifepristone–Misoprostol regimen is a safe and effective method for terminating pregnancies between 13 and 22 weeks in adolescents. Keywords: Adolescents, pregnancy termination, medical abortion, Mifepristone – Misoprostol combination.