ĐẶC ĐIỂM ĐỘT BIẾN GEN THROMBOPHILIA Ở PHỤ NỮ CÓ TIỀN SỬ SẨY THAI, THAI LƯU TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG

Abstract

Background: Thrombophilia is a group of hereditary or acquired prothrombotic disorders, has recently attracted considerable attention and remains controversial. Objective: This study aimed to describe the characteristics of thrombophilic gene mutations and several related factors in women with a history of miscarriage. Methods: A cross-sectional study was conducted on 365 women with a history of miscarriage of unknown cause who attended the National Hospital of Obstetrics and Gynecology in 2023. Results: Most women with a history of miscarriage carried at least one thrombophilic gene mutation. However, no significant difference was observed in the mutation rates between women with a single miscarriage and those with recurrent miscarriage. The two most frequently identified mutations were PAI-1 and MTHFR A1298C, accounting for 81% and 47.9%, respectively. Prothrombin/FII 20210A and Factor V Leiden mutations were rare and are not considered major causes of miscarriage in Vietnamese women. No correlation was found between the total number of mutated alleles and the occurrence of recurrent miscarriage.