TÌNH TRẠNG NHIỄM VIRUS VIÊM GAN D VÀ MỐI LIÊN QUAN VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG Ở THAI PHỤ QUÝ III THAI KỲ CÓ HBSAG

Abstract

Background: Co-infection with hepatitis D virus (HDV) and hepatitis B virus (HBV) exacerbates severity of liver disease. During pregnancy, particularly in the third trimester, this co-infection poses significant risks to maternal and neonatal health. Objective: This study aimed to investigate the prevalence of HDV infection among pregnant women with HBsAg. Material and methods: A cross-sectional study on 250 pregnant women who tested positive for HBsAg in their third trimester. Serum samples were collected and tested for HDV markers using a chemiluminescence immunoassay (CLIA). Confirmation and genotyping of HDV were conducted using nested PCR. The association of HDV infection status with clinical parameters and pregnancy outcomes was analysed. Results: The results indicated that 8 out of 250 participants (3.2%) tested positive for elevated levels of anti-HDV. However, no cases of HDV-RNA were detected. The prevelance of anti-HDV antibodies in pregnant women from the North (75%) was higher compared to those from the South of Vietnam (25%). Creatinine levels were significantly lower, and prothrombin time (PT) was significantly longer in the anti-HDV-positive group than in the anti-HDV-negative group (p=0.01 and 0.006, respectively). No significant differences were found between the two groups for other parameters (p>0.05). Though not statistically significant, the birth weight of infants in the anti-HDV-positive group was slightly higher. Conclusion: The prevalence of HDV infection among third-trimester pregnant women is 3.2%, and HDV infection is associated with prolonged coagulation time and reduced serum creatinine levels.