MỐI LIÊN QUAN GIỮA FERRITIN HUYẾT THANH VỚI ĐƯỜNG HUYẾT LÚC ĐÓI, HBA1C VÀ MỘT SỐ BỆNH MẠN TÍNH Ở NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG TÍP 2

Abstract

Background: Serum ferritin is a commonly used index to assess increased iron stores in patients with diabetes mellitus (DM). Some studies have shown that patients with DM have higher mean serum ferritin concentrations than individuals without the disease. Additionally, serum ferritin concentrations have been reported to correlate with blood glucose and glycosylated hemoglobin (HbA1c). However, this relationship has not yet been clearly established, especially concerning the effects of gender and age. Method: This cross-sectional study collected data from 273 type 2 diabetes patients who had outpatient examinations at Le Van Thinh hospital, Ho Chi Minh City, between January and May 2024. Test data were retrospectively gathered and combined with available medical records to collect comprehensive information. Results: Serum ferritin concentration was significantly higher in men at 139 (83 - 297) ng/mL compared to women at 112 (53 - 277) ng/mL (p=0.02). There was a difference in median ferritin concentrations in diabetic patients with comorbidities of hypertension (p=0.03), dyslipidemia (p<0.001), and chronic kidney disease (p=0.04) compared to the group without these comorbidities. There was a positive correlation between ferritin concentrations and fasting blood glucose (r=0.38 and p<0.001), HbA1c (r=0.18 and p=0.04), and a negative correlation with serum creatinine (with a correlation coefficient r of -0.31 and p<0.001. Conclusion: The study found a correlation between ferritin and fasting blood glucose/HbA1c, and also noted an increase in serum ferritin levels in type 2 diabetic patients with comorbidities of hypertension and dyslipidemia. However, this association requires further investigation with control for other influencing factors.