HYPOCALCINEMIA IN CHILDREN LESS THAN 2 YEARS OF AGE: CLINICAL AND BIOCHEMISTRY CHARACTERISTICS
Main Article Content
Abstract
Hypocalcemia is common emergency disorder in children, especially children less than 2 years of age. Diversity of clinical manifestations are from asymptomatic, convulsions, lethargy, poor feeding, and severe cases hospitalized with cardiogenic shock, arrhythmia. Objectives: to describe the clinical and biochemistry characteristics of hypocalcaemia in children less than 2 years of age. Patients and methods: 20 children less than 2 years of age were diagnosed with hypocalcemia treated at the National Children's Hospital during 18 months (Oct 2019 to Apr 2021). This is descriptive case series study. Results: The disorder is most common in children less than 2 months of age (80%) with symptoms of convulsions (95%), irritation - crying, lethargy, in addition, two cases presented with cardiac arrhythmia extended Qtc. Blood calcium levels were severely reduced with total calcium levels 1.32±0.22 mmol/l, ion calcium levels 0.7±0.15 mmol/l. Vitamin D deficiency was proved in both child and the child's mother. Conclusion: Hypocalcemia is common in children less than 2 months of age. The main clinical symptom was seizures. Supplementing vitamin D for children right after birth, supplementing with a reasonable diet rich in calcium and vitamin D for mothers during pregnancy and lactation helps to reduce the risk of hypocalcemia in children less than 2 years of age.
Article Details
Keywords
hypocalcaemia, Vitamin D deficiency in children less than 2 years of age
References
2. Muuns C.F ., Shaw N ., Kiely M., et al. 2016. Global consensus recommendation on prevention and management of nutritional rickets . J Clin Endocrinol Metab, 101(2):394-415
3. BinMohanna M.A., Raja’a Y.A., and Saif G.A. (2005). Prevalence of hypocalcemia in children examined for serum calcium in Sana’a, Yemen. Saudi Med J, 26(3), 457–459
4. Nguyễn Trọng Thành, Vũ Chí Dung. (2021). Đặc điểm lâm sàng, hóa sinh và một số nguyên nhân hạ canxi máu nặng ở trẻ bú mẹ. Tạp chí nghiên cứu y học, 140(4), 8-13.
5. Pankaj. (2011). Hypocalcemic cardiomyopathy presenting as cardiogenic shock. Annals of Pediatric Cadiology, 4(2):152-5.
6. Christopher S., Beate L., et al. (1996). Parathyroid hormone- related peptide (PTHrP) regulates fetal placental calcium transport through a receptor distinct from the PTH/ PTHrP receptor.Proc Nall Acad Sci U S A, 93(26):15233-15238.
7. Ismail J., Dawman L., Sankar J. (2015). Hypocalcemia, parathyroid hormone and calcitonin levels - association in critically ill children.Indian J Pediatr, 82(3), 210–211.