Article Sidebar
Views pdf: 152
THE EFFECTIVENESS OF PLATELET-RICH FIBRIN IN CONTROLLING PAIN, SWELLING AND SOFT TISSUE HEALING AFTER MANDIBULAR MOLAR EXTRACTION IN PATIENTS WITH TYPE 2 DIABETES
Main Article Content
Abstract
Objective: Evaluation of swelling, pain, and soft tissue healing after mandibular molar extraction using platelet-rich fibrin (PRF) in patients with type 2 diabetes. Subjects and Methods: A non-controlled clinical trial conducted on 32 patients with type 2 diabetes who underwent mandibular molar extraction with PRF application at Thong Nhat Hospital from August 2024 to March 2025. Postoperative parameters were monitored, including pain level (VAS), facial swelling, and soft tissue healing at multiple time points (days 1, 3, 7, 21, and 42). Results: Pain levels decreased progressively from day 1 to day 7 after surgery, with statistically significant differences (p < 0.001). Facial swelling slightly increased on day 1, then gradually subsided and returned close to baseline by day 7. Soft tissue characteristics showed positive improvement from day 7 and progressed markedly by days 21 and 42. The mean healing scores also improved over time, with significant differences observed between day 7 and days 21 and 42 (p < 0.001). Conclusion: The use of PRF in mandibular molar extraction for patients with type 2 diabetes demonstrated effective pain reduction, minimized swelling, and enhanced soft tissue healing, contributing to improved postoperative outcomes and quality of care.
Article Details
Keywords
Platelet-rich fibrin, mandibular molar extraction, type 2 diabetes, soft tissue healing.
References
2. Pham Thi Thanh, Nguyen Thi Mai, Nguyen Thi Ngoc Ha, Mai Thi Hien, Nguyen Dac Tu. Platelet-rich Plasma and Its Application in Clinical Trial. VNU Journal Of Science: Medical And Pharmaceutical Sciences. 2021;37(3):37-47.
3. Alissa R, Esposito M, Horner K, Oliver R. The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial. Eur J Oral Implantol. 2010 Summer;3(2):121-34.
4. Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S. Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review. Int J Implant Dent. 2021 Dec 19;7(1):117.
5. Asoka S, Panneerselvam E, Pandya AR, Raja VBK, Ravi P. Effect of platelet-rich fibrin on extraction socket healing in diabetic patients - A split-mouth crossover study: A prospective clinical trial. Natl J Maxillofac Surg. 2022;13(1):39-43.
6. Gazal G. Management of an emergency tooth extraction in diabetic patients on the dental chair. Saudi Dent J. 2020;32(1):1-6.
7. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. 2021.
8. Kaur P. Assessment of effect of platelet-rich fibrin on extraction socket healing in diabetic patients. Int J Life Sci Biotechnol Pharma Res. 2023;12(2):419-422.
9. Mozzati M, Gallesio G, di Romana S, Bergamasco L, Pol R. Efficacy of plasma-rich growth factor in the healing of postextraction sockets in patients affected by insulin-dependent diabetes mellitus. J Oral Maxillofac Surg. 2014 Mar;72(3):456-62.
10. Ozgul O, Senses F, Er N, Tekin U, Tuz HH, Alkan A, Kocyigit ID, Atil F. Efficacy of platelet rich fibrin in the reduction of the pain and swelling after impacted third molar surgery: randomized multicenter split-mouth clinical trial. Head Face Med. 2015 Nov 26;11:37.