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CLINICAL, PARACLINICAL, AND MICROBIOLOGICAL CHARACTERISTICS OF PATIENTS WITH BILIARY TRACT INFECTIONS DUE TO COMMON BILE DUCT STONES TREATED BY ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY AT BACH MAI HOSPITAL, 2024–2025
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Abstract
Objective: This study was conducted to describe the clinical features, laboratory findings, and microbial characteristics of patients with biliary tract infections caused by common bile duct (CBD) stones at Bach Mai Hospital during 2024–2025. Methods: A descriptive cross-sectional study, combining retrospective and prospective data collection, was carried out on 125 patients diagnosed with biliary tract infection due to CBD stones. All patients were admitted for inpatient treatment at the Department of Gastroenterology and Hepatology, Bach Mai Hospital, from August 2024 to May 2025. The results: The mean age was 65.4 ± 17.3 years, with a nearly equal distribution between males and females. The most common symptom was right upper quadrant abdominal pain, observed in 94.4% of patients. The rate of positive bile culture was 53.0%. Among the cultured microorganisms, Escherichia coli, Enterococcus spp., and Klebsiella spp. accounted for 40.0%, 28.9%, and 17.8%, respectively. E. coli and Klebsiella strains showed relatively low resistance to Amikacin and the Carbapenem group, while Enterococcus strains were generally susceptible to Vancomycin and Linezolid. Conclusion: E. coli was the most commonly isolated pathogen in patients with biliary tract infections caused by CBD stones, with relatively low resistance rates to Amikacin and Carbapenems.
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Keywords
Cholangitis, bile culture, common bile duct stone.
References
2. Cương NC, Hưng TV, Thi NV, Quang PV, Dũng HT. Kết quả điều trị cấp cứu viêm đường mật cấp do sỏi. Published online 2018.
3. Mohan R, Wei Lynn Goh S, Tan GW, et al. Validation of Tokyo Guidelines 2007 and Tokyo Guidelines 2013/2018 Criteria for Acute Cholangitis and Predictors of In-Hospital Mortality. Visc Med. 2021;37(5): 434-442. doi:10.1159/ 000516424
4. Hamdi A, Yetmar ZA, Miller AT, Diaz M, Fida M, Beam E. 148. Retrospective Evaluation of Acute Cholangitis and Clinical Implication and Management of Secondary Bacteremia. Open Forum Infect Dis. 2019;6(Suppl 2):S101. doi:10.1093/ofid/ofz360.223
5. Raghhupatruni P, Gopalakrishna R, Ankarath V, Sadasivan S. Profile and Outcome of Patients with Acute Cholangitis in a Tertiary Center in South India. Journal of Digestive Endoscopy. 2021;12(03):127-132. doi:10.1055/s-0041-1739561
6. Inan O, Sahiner ES, Ates I. Factors associated with clinical outcome in geriatric acute cholangitis patients. Eur Rev Med Pharmacol Sci. 2023;27(8): 3313-3321. doi:10.26355/eurrev_202304_32102
7. Gromski MA, Gutta A, Lehman GA, et al. Microbiology of bile aspirates obtained at ERCP in patients with suspected acute cholangitis. Endoscopy. 2022;54(11):1045-1052. doi:10.1055/ a-1790-1314
8. Gu XX, Zhang MP, Zhao YF, Huang GM. Clinical and microbiological characteristics of patients with biliary disease. World J Gastroenterol. 2020;26(14): 1638-1646. doi:10. 3748/wjg.v26.i14.1638
9. Li Y, Li D, Huang X, Long S, Yu H, Zhang J. Temporal Shifts in Etiological Agents and Antibiotic Resistance Patterns of Biliary Tract Infections in Sichuan Province, China (2017–2023). Infect Drug Resist. 2024;17:4377-4389. doi:10.2147/IDR.S474191
10. Liu T, Li M, Tang L, et al. Epidemiological, clinical and microbiological characteristics of patients with biliary tract diseases with positive bile culture in a tertiary hospital. BMC Infectious Diseases. 2024;24(1):1010. doi:10.1186/s12879-024-09799-8