Article Sidebar
Views pdf: 159
Introduction: Mortality due to septic shock remains high and is influenced by various factors depending on the clinical context and the stage of the disease. Objective: To investigate several factors associated with 30-day mortality in patients with septi
Main Article Content
Abstract
Introduction: Mortality due to septic shock remains high and is influenced by various factors depending on the clinical context and the stage of the disease. Objective: To investigate several factors associated with 30-day mortality in patients with septic shock, aiming to improve treatment, care, monitoring, and prognosis. Methods: A descriptive cross-sectional study was conducted on 165 patients diagnosed with septic shock according to the Sepsis-3 definition, admitted to the Intensive Care Unit at Hoan My Cuu Long General Hospital from January 2023 to March 2025. Results: The 30-day mortality rate was 40.6%. Multivariate logistic regression analysis revealed that the following factors were associated with 30-day mortality: Charlson Comorbidity Index (OR = 1.31; 95% CI: 1.00–1.70), white blood cell count (OR = 0.96; 95% CI: 0.92–1.00), serum albumin (OR = 0.29; 95% CI: 0.11–0.76), arterial pH <7.35 (OR = 2.99; 95% CI: 1.01–8.86), APACHE II score (OR = 1.09; 95% CI: 1.01–1.18), and refractory shock (OR = 5.22; 95% CI: 2.17–12.53). Among these, the APACHE II score had the best predictive value for 30-day mortality, with an AUC of 0.755 (95% CI: 0.680–0.830), at a cutoff point of 18.5, the sensitivity was 0.836 and specificity was 0.561 (p <0.001). Conclusion: Comorbidities assessed by the Charlson index, white blood cell count, serum albumin, arterial pH <7.35, APACHE II score, and refractory shock were identified as factors associated with 30-day mortality in patients with septic shock
Article Details
Keywords
Septic shock, mortality-related factors, Charlson comorbidity index, albumin, arterial pH.
References
2. Daviaud, F., Grimaldi, D., Dechartres, A., et al. (2015), "Timing and causes of death in septic shock", Ann Intensive Care. 5(1), p. 16. doi:10.1186/s13613-015-0058-8.
3. Reaven, M. S., Rozario, N. L., McCarter, M. S. J., et al. (2022), "Incidence and risk factors associated with early death in patients with emergency department septic shock", Acute Crit Care. 37(2), pp. 193-201. doi:10.4266/acc.2021. 00857.
4. Bauer, M., Gerlach, H., Vogelmann, T., et al. (2020), "Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis", Crit Care. 24(1), p. 239. doi: 10.1186/s13054-020-02950-2.
5. Charlson, M. E., Carrozzino, D., Guidi, J., et al. (2022), "Charlson Comorbidity Index: A Critical Review of Clinimetric Properties", Psychother Psychosom. 91(1), pp. 8-35. doi: 10.1159/000521288.
6. Nguyễn Thành Luân, Nguyễn Việt Thu Trang (2025), "Sốc nhiễm khuẩn tại Bệnh viện Hoàn Mỹ Cửu Long: Kết quả điều trị và một số yếu tố tiên lượng", Tạp chí Nghiên cứu Y học. 186(1), pp. 208-215. https://doi.org/10.52852/tcncyh.v186i1. 2981.
7. Thomas-Rüddel, D. O., Fröhlich, H., Schwarzkopf, D., et al. (2024), "Sepsis and underlying comorbidities in intensive care unit patients: Analysis of the cause of death by different clinicians-a pilot study", Med Klin Intensivmed Notfmed. 119(2), pp. 123-128. doi: 10.1007/s00063-023-01037-4.
8. Wernly, Bernhard, Heramvand, Nadia, Masyuk, Maryna, et al. (2020), "Acidosis predicts mortality independently from hyperlactatemia in patients with sepsis", European Journal of Internal Medicine. 76, pp. 76-81. doi: 10.1016/j.ejim.2020.02.027.
9. Nandhabalan, P., Ioannou, N., Meadows, C., et al. (2018), "Refractory septic shock: our pragmatic approach", Crit Care. 22(1), p. 215. doi: 10.1186/s13054-018-2144-4.
10. Belok, S. H., Bosch, N. A., Klings, E. S., et al. (2021), "Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction", PLoS One. 16(6), p. e0252206. doi:10.1371/ journal.pone.0252206.