ETIOLOGY OF ANTERIOR UVEITIS AT NATIONAL INSTITUTE OF OPHTHALMOLOGY

Thị Loan Hoàng, Thị Thu Hà Hoàng, Đỗ Thị Ngọc Hiên Nguyễn

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Abstract

Purpose: To determine the etiological distribution and clinical characteristics of anterior uveitis at the National Institute of Ophthalmology. Methods: A cross-sectional descriptive study was conducted at the National Institute of Ophthalmology from September 2023 to June 2025. All patients underwent comprehensive clinical examinations and laboratory tests to determine the etiology. Collected data included age, sex, medical history, clinical features, and underlying causes. Results: A total of 43 patients (54 eyes) met the inclusion criteria. The mean age was 46.14 ± 14.73 years (range: 14 to 69), with 22 males (51.2%). Best-corrected visual acuity ranged from 0 to 2.0 logMAR, with a mean of 0.462 ± 0.523 logMAR. Eighteen eyes (33.3%) had elevated intraocular pressure (IOP), and there was a statistically significant association between viral anterior uveitis and elevated IOP (p < 0.05). 32 patients (74,4%) had unilateral anterior uveitis. Infectious anterior uveitis accounted for 53.5%, which was more common than non-infectious causes (46.5%). Among infectious etiologies, cytomegalovirus (CMV) was the most common (32.6%), followed by herpes simplex virus (HSV, 9.3%) and varicella-zoster virus (VZV, 4.7%). Among non-infectious cases, idiopathic anterior uveitis was the most frequent (39.5%). Conclusion: This study demonstrates that infectious anterior uveitis is common, with CMV being the most frequently identified pathogen.

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References

Samalia, P., Sims, J. & Niederer, R. The Role of Ageing in the Clinical Presentation of Uveitis. Am J Ophthalmol 272, 58–66 (2025).
2. Nguyen, M., Siak, J., Chee, S.-P. & Diem, V. Q. H. The Spectrum of Uveitis in Southern Vietnam. Ocul Immunol Inflamm 25, S100–S106 (2017).
3. Do, H. D. et al. Pattern of Uveitis in Northern Vietnam. Ocular Immunology and Inflammation 1–12 (2024).
4. Lê Xuân Hùng. Nghiên cứu ứng dụng kỹ thuật phản ứng chuỗi Polymerase để phát hiện CMV, HSV trong thủy dịch của hội chứng Posner Schlossman [luận văn thạc sĩ]. Hà Nội: Đại học Y Hà Nội; 2012.
5. Kongyai, N. et al. Viral causes of unexplained anterior uveitis in Thailand. Eye 26, 529–534 (2012).
6. Kalogeropoulos, D. et al. The large Hellenic Study of Uveitis: epidemiology, etiologic factors and classification. Int Ophthalmol 43, 3633–3650 (2023).
7. Hsiao, Y.-T., Kuo, M.-T., Chiang, W.-Y., Chao, T.-L. & Kuo, H.-K. Epidemiology and clinical features of viral anterior uveitis in southern Taiwan—diagnosis with polymerase chain reaction. BMC Ophthalmol 19, 87 (2019).
8. Chee, S.-P. & Jap, A. Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. Am J Ophthalmol 146, 883-889.e1 (2008).