NỒNG ĐỘ VITAMIN D HUYẾT THANH Ở BỆNH NHÂN VIÊM DA TIẾT BÃ

Abstract

Objective: To determine the serum vitamin D levels in patients with seborrheic dermatitis and assess the association between vitamin D levels and disease severity. Subjects and Methods: A descriptive cross-sectional study was conducted on 45 patients with seborrheic dermatitis and 45 healthy controls at the Ho Chi Minh City Hospital of Dermatology and Venereology. Serum 25(OH)D levels were measured using electrochemiluminescence immunoassay (ECLIA). Disease severity was evaluated using the Seborrheic Dermatitis Area Severity Index (SDASI). Statistical analyses included the Mann–Whitney U test, Chi-squared test, and Spearman correlation. Results: The median serum vitamin D level in the patient group was 21.9 ng/ml (IQR: 20.1–25.6), significantly lower than that of the control group (23.7 ng/ml; IQR: 21.4–29.5) (p = 0.01). The prevalence of vitamin D deficiency (<20 ng/ml) was 24.4% in patients compared to 8.9% in controls (p = 0.048). A moderate negative correlation was observed between serum vitamin D levels and SDASI scores (r = –0.4; p = 0.009). Patients with vitamin D levels <30 ng/ml had significantly higher SDASI scores than those with levels ≥30 ng/ml (p = 0.015). Conclusion: Patients with seborrheic dermatitis had lower serum vitamin D levels and a higher prevalence of deficiency compared to healthy individuals. Vitamin D levels were inversely correlated with disease severity, suggesting a potential role of vitamin D in the pathogenesis and