ĐÁNH GIÁ TÌNH TRẠNG KHÁNG INSULIN Ở PHỤ NỮ VÔ SINH CÓ HỘI CHỨNG BUỒNG TRỨNG ĐA NANG

Abstract

Objectives: To assess the status of insulin resistance in infertile women with polycystic ovary syndrome. Subjects and methods: This was a cross-sectional, case-control descriptive study with analytical elements. The study population consisted of infertile patients, divided into two groups: Group 1 included patients diagnosed with polycystic ovary syndrome, and Group 2 included those without polycystic ovary syndrome. The study was conducted at the Military Institute of Clinical Embryology, Military Medical Academy, from September 2018 to May 2019. Insulin resistance in patients with polycystic ovary syndrome was defined by a HOMA-IR index greater than the upper quartile of the control group or a QUICKI index lower than the lower quartile of the control group. Results: The mean fasting insulin level in Group 1 (10.85 ± 5.85 µUI/ml) was significantly higher than that in Group 2 (7.44 ± 2.84 µUI/ml) (p<0.05). The mean fasting glucose level in Group 1 (4.97 ± 0.45 mmol/l) was also significantly higher compared to Group 2 (4.71 ± 0.47 mmol/l) (p<0.05). The prevalence of insulin resistance among patients with polycystic ovary syndrome was 57.5%, significantly higher than that in the non- polycystic ovary syndrome group (25%) (p<0.05). Notably, all three patients who required cycle cancellation exhibited insulin resistance. Conclusion: Insulin resistance in patients with polycystic ovary syndrome was reflected by elevated HOMA-IR and reduced QUICKI indices compared to the control group. The prevalence of insulin resistance among polycystic ovary syndrome patients in this study was 57.5%.