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CHROMOSOMAL DISORDERS OF EMBRYOS IN THE 5TH DAY WITH MOTHER’S AGE IN IN-VITRO FERTILIZATION
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Abstract
Objectives: The study performed on 60 infertile couples performing in vitro fertilization who have embryos of the 5th day with Next Generation Sequencing (NGS) in order to analyze the relationship between chromosomal disorders (chromosome) of embryos in the 5th day with mother's age. Method: Cross sectional study. Results: The chromosomal aneuploidy embryo in the maternal age group under 35 was 36.28%, the maternal age group 35-39 was 49.1% and the maternal age group over 40 years old was 54.0%. This study did not differ in type of chromosomal aneuploidy in different age groups. The results also show that, for every 22.87%, the change in the rate of chromosomal number disorders is explained by the variation of the maternal age factor (R-square determination coefficient = 0.22287). When the mother's age increases by 1 unit, the rate of chromosomal disorders will increase by 0.01 units. Conclusion: There is an association of maternal age with chromosomal aneuploidy. Increasing mother's age increases the incidence of chromosomal disorders
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Keywords
Chromosomal disorders, embryos of the 5th day, mother’s age, in vitro fertilization, Next Generation Sequencing
References
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