MỐI LIÊN QUAN GIỮA MỘT SÔ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ TỔN THƯƠNG XƠ HÓA CẦU THẬN TRONG BỆNH THẬN IGA

Abstract

Objective: Describe clinical and paraclinical characteristics and compare glomerulosclerosis lesions in 80 patients with IgA nephropathy. Subjects and methods: cross-sectional, prospective study on 80 patients with IgAN from September 2023 to January 2025. Results: The most common clinical symptoms were microscopic hematuria (75%) and hypertension (27.5%). The time from diagnosis to renal biopsy was 12.42 ± 25.67 months. The most common immune deposits were IgA in the mesangium (100%) and C3 in the mesangium (88.7%). The most common histopathological features were mesangial cell proliferation (27.5%) and focal glomerulosclerosis (57.5%). The rate of glomerulosclerosis was higher in the group of patients with hypertension and proteinuria ≥ 1g/day. The more mesangial C3 deposition, the more glomerulosclerotic lesions increased, the difference was statistically significant (p < 0.05). Conclusion: IgA nephropathy progresses silently for many years with symptoms of microscopic hematuria, but leads to glomerulosclerosis and renal function decline over time.