Article Sidebar

PDF
Date Published: 08/01/2022
Abstract Views: 263
Views PDF: 332
DOI: https://doi.org/10.51298/vmj.v508i2.1590
Issue
Vol. 508 No. 2 (2021)
Section
Các bài báo
How to Cite
Văn Bạch, N. ., Nam Trung, T. ., & Văn Minh, N. . (2022). FORMULATION OPTIMIZATION OF SALBUTAMOL SULFATE FAST DISSOLVING FILM. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1590

FORMULATION OPTIMIZATION OF SALBUTAMOL SULFATE FAST DISSOLVING FILM

Nguyễn Văn Bạch1,, Trịnh Nam Trung1, Nguyễn Văn Minh1
1 Vietnam Military Medical University

Main Article Content

Abstract

Objective: Using Modde 8.0 and INForm 3.1 software, to optimize the fast-dissolving film formulation of salbutamol sulfate 4mg. Methods: Preparation of films by method of casting and solvent evaporation, quantification of salbutamol sulfate in dissolution medium by UV spectroscopy, experimental design and optimization of formulations for fast dissolving film of salbutamol sulfate 4mg using Moddle 8.0 and INForm 3.1 software. Results: The percentage (%) of salbutamol sulfate released from the optimal formula and the prediction data of INForm 3.1 software are similar (at 30 minutes, 99.3% and 99.8% salbutamol sulfate were released from the optimal formula and data of INForm 3.1 software.). Conclusion: The optimal formula has been developed including: Salbutamol sulfate 666.67mg; PVA 2.01%; Glucose 1%; PG 0.0201%; Sodium lauryl sulfate 0.85%; Distilled water 20ml; Ethanol 70% added to 100 ml; 15 ml were cast into a 5cm diameter petri dish; films with a diameter of 10 mm.

Article Details

Keywords

Salbutamol sulfat, fast-dissolving film

References

1. Verma R., Sanjay G. (2001), Current status of drug delivery technologies and future directions, Pharm. Technol., 25, pp. 1-14.
2. Dipika p., Upendra P., et al. (2012), Orally fast dissolving films as dominant dosage form for quick release, IJPRBS, 1(3), pp. 27- 41.
3. Nhâm Phương Thảo, Nguyễn Văn Bạch, Nguyễn Minh Chính và CS (2015), Ảnh hưởng của một số tá dược đến độ giải phóng của salbutamol từ phim giải phóng nhanh đặt tại khoang miệng, Tạp chí Y Dược học quân sự, Vol 40 (06), tr. 11-16.
4. Apoorva M., Neha C., Geeta A. (2011), Formulation and characterization of fast dissolving buccal films: A review, Der. Phar. Lettre, 3(1), pp. 152-165.
5. Mishra R., Amin A. (2005), Quick API Delivery, Pharmaceutical Technology Europe, pp. 1-5.
6. Prasanthi N. L., Sowmya K. C. et al. (2011), Design and development of sublingual fast dissolving films for an antiasthmatic drug, Der Pharmacia Lettre, 3(1), pp. 382-395.