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Date Published: 29/10/2025
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DOI: https://doi.org/10.51298/vmj.v555i1.15903
Issue
Vol. 555 No. 1 (2025)
Section
Các bài báo
How to Cite
Trần, H. L., Đỗ, D. C., & Hoàng, X. S. (2025). CHARACTERISTICS OF LIVER INJURY AND ASSOCIATED FACTORS IN PATIENTS WITH DENGUE HEMORRHAGIC FEVER. Vietnam Medical Journal, 555(1). https://doi.org/10.51298/vmj.v555i1.15903

CHARACTERISTICS OF LIVER INJURY AND ASSOCIATED FACTORS IN PATIENTS WITH DENGUE HEMORRHAGIC FEVER

Hoàng Long Trần, Duy Cường Đỗ, Xuân Sử Hoàng

Main Article Content

Abstract

Objective: To describe the status of liver injury and related factors in patients with Dengue hemorrhagic fever. Subjects and Methods: A descriptive study was conducted on 295 patients with Dengue hemorrhagic fever treated at the Center for Tropical Diseases, Bach Mai Hospital, from October 2022 to December 2023. Results: Dengue hemorrhagic fever was observed across all age groups and exhibited a relatively balanced distribution between sexes. Regarding the assessment of liver injury, we observed statistically significant elevations in AST/ALT levels and the APRI score in the severe patient group. An APRI value of 12.43 demonstrated the highest diagnostic performance for severe Dengue hemorrhagic fever, with a sensitivity of 85.0% and a specificity of 73.8%. Furthermore, pro-inflammatory cytokines such as IL-18 and CXCL-10 show considerable potential in prognosticating liver injury in patients with Dengue hemorrhagic fever.

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References

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