NGHIÊN CỨU GIÁ TRỊ CỦA CHỈ SỐ BẠCH CẦU HẠT CHƯA TRƯỞNG THÀNH TRONG CHẨN ĐOÁN NHIỄM KHUẨN HUYẾT TẠI BỆNH VIỆN NHI ĐỒNG THÀNH PHỐ CẦN THƠ

Abstract

Background: Sepsis remains one of the leading causes of mortality in children. The immature granulocyte (IG) index is a promising biomarker that can assist in diagnosing pediatric sepsis without incurring additional costs. Objectives: (1) To determine the correlation between the immature granulocyte index and the levels of C-reactive protein (CRP) and procalcitonin in the diagnosis of sepsis; (2) To evaluate the AUC value, optimal cutoff point, sensitivity, and specificity of the immature granulocyte index in the diagnosis of sepsis. Materials and Methods: A cross-sectional descriptive study was conducted on 220 pediatric patients diagnosed with infection at Can Tho Children’s Hospital. Results: The absolute IG count (IG#) showed a positive correlation with CRP (r = 0.61) and procalcitonin (r = 0.86). The AUC for IG# was 0.78 with an optimal cutoff value of 0.28 G/L, yielding a sensitivity of 70% and specificity of 76%. The AUC for IG% was 0.80, with an optimal cutoff point of 1.25%, sensitivity of 73%, and specificity of 78%. Conclusion: The IG index is a reliable biomarker for the diagnosis of pediatric sepsis. It can be used in combination with other laboratory parameters to support clinicians in monitoring and managing septic children effectively.