TỔN THƯƠNG ĐƯỜNG TIÊU HÓA VÀ CÁC YẾU TỐ LIÊN QUAN Ở BỆNH NHÂN XƠ CỨNG BÌ

Abstract

Objectives: (1) To assess the manifestations of gastrointestinal (GI) involvement in patients with systemic sclerosis (SSc) using the GIT 2.0 questionnaire.(2) To analyze factors associated with GI involvement in this patient population. Methods: A cross-sectional descriptive. Subjects: 70 patients diagnosed with SSc at the Rheumatology Center, Bach Mai Hospital and Hanoi Medical University Hospital from August 2024 to August 2025. Results: The average age of the study population was 58.1 ± 13.4 years, with 72.9% aged over 50 years. Most patients had a disease duration of less than two years (61.4%), and diffuse cutaneous SSc was the predominant subtype (67.1%). The majority of patients were female, with a female-to-male ratio of 4:1. GI involvement was mostly mild, but 68.5% had moderate-to-severe reflux and 24.3% had fecal soilage. Diffuse cutaneous SSc was associated with higher gastroesophageal reflux scores and poorer emotional well-being than limited cutaneous SSc. In addition, patients with moderate-to-very-severe gastroesophageal reflux symptoms had a higher prevalence of interstitial lung disease than those with absent or mild symptoms. Conclusion: Reflux subscales was the most frequently reported moderate to very severe GI symptom. Patients with diffuse cutaneous SSc and disease duration greater than 2 years had more severe GI involvement and greater mental health burden than those with limited cutaneous SSc and disease duration of 2 years or less