MỐI LIÊN QUAN GIỮA LÂM SÀNG, CẬN LÂM SÀNG, KẾT QUẢ ĐIỀU TRỊ VỚI TÌNH TRẠNG GIẢM ALBUMIN MÁU Ở TRẺ SỐT XUẤT HUYẾT DENGUE NẶNG TẠI BỆNH VIỆN NHI ĐỒNG CẦN THƠ

Abstract

Introduction: Hypoalbuminemia in dengue fever is an important prognostic marker, associated with disease severity and treatment outcomes. Objective: To determine the association between hypoalbuminemia and selected clinical factors, paraclinical factors, and treatment outcomes in children with severe dengue. Methods: A cross-sectional analytic study was conducted on 88 pediatric patients meeting the inclusion criteria at Can Tho Children's Hospital. Results: Serum albumin levels were significantly lower in children with severe dengue who presented with increased vascular permeability. Hypoalbuminemia was strongly associated with clinical signs of plasma leakage and coagulopathy. Recurrent shock, platelet count <50,000/mm³, and fluid administration before shock were independent factors associated with hypoalbuminemia (p<0.05). Conclusions: Hypoalbuminemia in children with severe dengue is closely associated with plasma leakage, coagulopathy, and several severe clinical features, reflecting the severity of the disease and aiding in prognosis and treatment planning.