ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN SỐT XUẤT HUYẾT DENGUE NẶNG TẠI KHOA HỒI SỨC TÍCH CỰC BỆNH VIỆN E NĂM 2023

Abstract

Objective: To describe the clinical and paraclinical characteristics as well as major complications of patients with severe dengue fever treated at the Intensive Care Unit (ICU) of E Hospital in 2023. Subjects and Methods: A descriptive observational study was conducted on 100 patients aged ≥18 years, diagnosed with severe dengue fever (based on positive NS1 antigen or IgM/IgG antibodies and meeting severity criteria), and treated in the ICU from July 1, 2023, to December 31, 2023. Results: The mean age was 48.3 ± 18.6 years, with 65% being male. Nearly half were aged ≥ 50 years. The most common symptoms were fever (81%) and myalgia (52%). Laboratory findings showed markedly elevated AST (1456.5 ± 2271.7 UI/L), ALT (628.6 ± 1015.4 UI/L), NT-proBNP (1118.9 ± 3725.1 pg/mL), procalcitonin, and severe thrombocytopenia (49.2 ± 53.9 G/L). Secondary infections occurred in 31% of cases, predominantly pneumonia (68%) and sepsis (20%). 19% required mechanical ventilation, and 15% underwent CRRT. Mortality or non-recovery rate was 19%, with 74% fully recovered and 6% with sequelae. Average ICU stay was 6.4 days. Conclusions: Severe dengue fever at E Hospital presented with multi-organ involvement, especially in older patients, with a notable rate of mortality and sequelae. Early recognition of warning signs and timely intervention in the ICU play a decisive role in treatment outcomes