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Date Published: 08/01/2022
Abstract Views: 282
Views PDF: 155
DOI: https://doi.org/10.51298/vmj.v508i2.1598
Issue
Vol. 508 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Anh Đào, L. ., & Thị Anh, L. . (2022). INITIAL STEP OF ASSESSING THE RESULT OF FOLAT TREATMENT IN RECURRENT PREGNANCY LOSS PATIENTS CARRYING THE MTHFR MUTATED GENE. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1598

INITIAL STEP OF ASSESSING THE RESULT OF FOLAT TREATMENT IN RECURRENT PREGNANCY LOSS PATIENTS CARRYING THE MTHFR MUTATED GENE

Lê Thị Anh Đào1,, Lưu Thị Anh2
1 Hanoi Medical University
2 Hanoi Obstetrics and Pediatrics Hospital

Main Article Content

Abstract

Recurrent pregnancy loss (RPL) and gene MTHFR polymorphism have been found to be strongly associated in Asian people. Folate treatment is believed to reduce blood homocysteine ​​levels and improve pregnancy outcomes. Objective: the study aims to evaluate the results of folate treatment in patients carrying the MTHFR C677T polymorphism at Hanoi Obstetrics and Gynecology Hospital. A cross-sectional study of 30 patients with a history of RPL and MTHFR mutation was treated with 5 mg folate/day during 3 months. Results 100% of patients carried the CT heterozygous MTHFR gene. The average concentration of homocysteine ​​before and after treatment was 10.3±3.47; 6.8±2.48 µmol/l respectively, (p=0,000). Conclusion: Folate treatment during 3 months reduces homocysteine ​​levels in the blood.

Article Details

Keywords

recurrent pregnancy loss, MTHFR, methyl folat

References

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