KẾT QUẢ ĐIỀU TRỊ THỞ ÁP LỰC DƯƠNG LIÊN TỤC Ở BỆNH NHÂN NGƯNG THỞ TẮC NGHẼN KHI NGỦ TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ

Abstract

Background: The prevalence of obstructive sleep apnea (OSA) is steadily increasing in the general population, markedly compromising patients’ quality of life and elevating the risk of associated complications. Although continuous positive airway pressure (CPAP) therapy has been proven effective, empirical data from Viet Nam remain limited. Objectives: To evaluate the therapeutic outcomes of continuous positive airway pressure in patients with obstructive sleep apnea. Materials and methods: A interventional study without control group enrolled 66 adults with OSA treated at Can Tho University of Medicine and Pharmacy Hospital from May 2024 to May 2025. Results: The male-to-female ratio was approximately 2:1. Mean age was 60.23 ± 16.58 years, with individuals ≥ 65 years accounting for 50.0%. Mean body-mass index was 25.76 ± 4.84 kg/m²; obesity prevalence was 57.6%. High-risk neck and waist circumferences were observed in 81.8% and 71.2% of participants, respectively. The most common comorbidities were hypertension (45.5%), chronic obstructive pulmonary disease (21.2%), diabetes mellitus (13.6%), and asthma (7.6%). The mean baseline ESS score was 11.42 ± 3.86. ESS values declined to 10.83 ± 3.44 at 2 weeks, 8.66 ± 2.47 at 1 month, and 5.47 ± 1.98 at 6 months (all p < 0.001). Median baseline AHI was 18.15 events·h⁻¹, changing to 18.10 at 2 weeks (p = 0.135) and decreasing to 14.80 and 12.05 at 1 and 6 months, respectively (both p < 0.001). Median ODI decreased from 20.90 events·h⁻¹ at baseline to 20.00 at 2 weeks (p = 0.064), 17.45 at 1 month, and 15.88 at 6 months (both p < 0.001). SpO₂ improved significantly at all follow-up points (p < 0.05). Conclusion:  CPAP therapy produced rapid and sustained improvements in daytime sleepiness, Epworth, AHI, ODI, and SpO₂ among patients with OSA.