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Date Published: 05/05/2021
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DOI: https://doi.org/10.51298/vmj.v498i2.160
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Vol. 498 No. 2 (2021)
Section
Các bài báo
How to Cite
Văn Chủ, N., & Lê Giang, T. (2021). MSI STATUS OF COLORECTAL ADENOCARCINOMA IN STAGE I-II. Vietnam Medical Journal, 498(2). https://doi.org/10.51298/vmj.v498i2.160

MSI STATUS OF COLORECTAL ADENOCARCINOMA IN STAGE I-II

Nguyễn Văn Chủ, Trần Lê Giang

Main Article Content

Abstract

Background: Microsatellite instability status (MSI) has been identified as a reliable prognostic indicator in stage I-II CRC, with an additional role in predicting the lack of benefit of 5-FU-based adjuvant chemotherapy. Purpose: To review some relationships between MSI status, clinical patterns and stages, pathological characteristics in colorectal cancer. Methods: 53 patients were diagnosed as colorectal adenocarcinoma in stage I-II that are evaluated by pathological features, and IHC stain with MLH1, MSH2, MSH6, PMS2. Results: MSI-H tumors had a higher incidence than MSS / MSI-L tumors in stage I and lower in stage II (32.2; 68.8 vs. 24.3; 75.7% respectively). Conclusion: MSI-H CRCs has a higher incidence than MSS / MSI-L tumors in stage I and lower in stage II. In which, the LS pattern has a high rate in stage II and the lowest in stage I.

Article Details

Keywords

MSI, Histopathology and Immunohistochemistry

References

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