MỐI LIÊN QUAN GIỮA HỆ SỐ KHUẾCH TÁN BIỂU KIẾN TRÊN CỘNG HƯỞNG TỪ VỚI MỘT SỐ ĐẶC ĐIỂM MÔ BỆNH HỌC VÀ PHẪU THUẬT CỦA UNG THƯ BIỂU MÔ CỔ TỬ CUNG

Abstract

Background: Current data regarding the association between the apparent diffusion coefficient (ADC) derived from magnetic resonance imaging (MRI) and selected histopathological and surgical characteristics of cervical cancer—such as tumor size, location, and cancer staging—remain limited. Objectives: To investigate the relationship between ADC values on MRI and certain histopathological and surgical characteristics of cervical carcinoma. Materials and methods: This was a cross-sectional descriptive-analytic study conducted on 35 patients with cervical cancer who underwent surgery and had histopathological confirmation at Hue University of Medicine and Pharmacy Hospital and Hue Central Hospital from March 2022 to August 2024. Results: The mean ADC value was significantly higher in tumors located at the anterior wall compared to other locations (p = 0.007). Tumor size showed a highly significant difference (p < 0.001), with smaller lesions tending to have higher ADC values. Other factors, including vaginal invasion, parametrial and broad ligament invasion, and lymph node metastasis, showed no statistically significant differences in mean ADC values (p > 0.05). Additionally, there was a moderately strong negative correlation (r = –0.507) between ADC and tumor size, which was statistically significant (p = 0.003). Mean ADC values tended to decrease with advancing clinical stage, from 1430.33 ± 305.61 in stage IA to 1106.60 ± 507.84 in stage III, with statistical significance (p = 0.007). Conclusion: ADC values on MRI show a negative correlation with tumor size and stage in cervical carcinoma, and are higher in tumors located at the anterior wall compared to other sites. These findings suggest that ADC may serve as a supplementary parameter in tumor characterization and clinical risk stratification in patients with cervical carcinoma.