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ETIOLOGY, CLINICAL AND LABORATORY CHARACTERISTICS OF INFECTIOUS MENINGITIS IN CHILDREN UNDER 3 MONTHS AT THE NATIONAL CHILDREN'S HOSPITAL
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Abstract
Introduction: Bacterial meningitis is a common, frequent and dangerous infectious disease worldwide in all ages, especially in infants under 3 months. Research method: A cross-sectional descriptive study design was used with data collected at the Neonatal Center and the Infectious Desease Center of the National Children's Hospital from June 1st, 2023 to May 30th, 2025. Variables included clinical and laboratory symptoms according to the cause of infected meningitis. Results: During the study period, a total of 90 patients under 3 months of age were diagnosed with infectious meningitis with positive microbiological results. Of which, the proportion of males accounted for 53.33%, females accounted for 46.67%. Regarding the distribution of microbial causative groups classified from the results of blood culture, CSF, multiplex PCR CSF, G.B.S. was the most common cause group (accounting for 38.89%), followed by E.Coli (accounting for 34.44%) and Seratina marcescen (accounting for 6.68%). The prominent clinical signs of VMNNK patients under 3 months of age were: Fever (66.67%), poor feeding and refusal to feed (54.44%), impaired perception (36.56%), jaundice and skin resorption in 22% of patients. Prominent paraclinical symptoms of meningitis in children under 3 months: average increase in CSF protein of 3.45 g/l, average decrease in glucose of 1.57 mmol/dl, average increase in cell count of over 2300 cells/mm3, brain damage on MRI and/or CT-scanner of the brain in 46.67%. Conclusion: GBS and E.coli are the two main groups of microorganisms causing meningitis in children under 3 months old; the prominent clinical features of patients with meningitis in newborns are fever, poor feeding and refusal to feed, and altered consciousness; the prominent laboratory features are increased CSF cells and proteins, and the rate of brain damage on MRI and/or CT scan of the brain is approximately half of the patients studied
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Keywords
Newborn, infectious meningitis, GBS, E.coli.
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