ASSESSMENT OF COMPLIANCE WITH LEVOTHYROXINE IN ELDERLY PATIENTS WITH HYPOTHYROIDISM AT FRIENDSHIP HOSPITAL

Phạm Thị Hằng1,, Nguyễn Quang Bảy2,3
1 Friendship Hospital
2 Bach Mai Hospital
3 Hanoi Medical University

Main Article Content

Abstract

Objective: To determine the rate of adherence to using Levothyroxine (L-T4) and related factors in elderly patients with primary hypothyroidism at the Endocrinology clinic, Huu Nghi hospital. Subjects and methods: a cross-sectional descriptive study on 82 primary hypothyroidism patients, aged 60 to 87 years, who attended the medical examination at the Endocrine Clinic, Huu Nghi Hospital from August 2020 to August 2021. Tests were conducted including TSH, FT4. Results and discussion: 85.4% of patients adhered to drug treatment. Level of information communication: high 69.5%; average 15.9%; as low as 14.6%. There were 78.1% reaching the treatment target (Euthyroid), 21.9% not reaching the treatment goal. The factors related to the L-T4 adherence rate were education level (OR = 11.8; 95% CI: 2.6-54.3) and treatment goals (OR = 4.8). , 95% CI: 1.3-17.6). Conclusion: The rate of adherence to using L-T4 in elderly primary hypothyroidism patients is about 85.4%. Factors related to adherence to L-T4 drug use: Education level and treatment goals. Recommendations: instruct patients to refer to documents, books, magazines, the internet and the guidance of medical staff about hypothyroidism.

Article Details

References

1. Mateo RCI, Hennessey JV. Thyroxine and treatment of hypothyroidism: seven decades of experience. Endocrine. 2019; 66(1): 10-17. doi:10.1007/s12020-019-02006-8.
2. Cappelli C, Castello R, Marini F, et al. Adherence to Levothyroxine Treatment Among Patients With Hypothyroidism: A Northeastern Italian Survey. Front Endocrinol (Lausanne). 2018;9:699. Published 2018 Nov 23. doi:10.3389/fendo.2018.00699. PMID: 30532737;
3. Wilmar M.Wiersinga (2004), Adult Hypothyroidism, Endocrinology. Volume 2(14th edition), tr. 1491-1506.
4. Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008 May; 10(5):348-54. doi: 10.1111/ j.1751-7176.2008.07572.x. PMID: 18453793;
5. Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR. High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over. J Clin Endocrinol Metab. 2009;94(4):1342-1345. doi:10.1210/jc.2008-1696.
6. Kumar P, Khandelwal D, Mittal S, Dutta D, Kalra S, Katiyar P, Aggarwal V. Knowledge, Awareness, Practices and Adherence to Treatment of Patients with Primary Hypothyroidism in Delhi. Indian J Endocrinol Metab. 2017 May-Jun;21(3):429-433. doi: 10.4103/ijem.IJEM_49_17. PMID: 28553600;