MỐI LIÊN QUAN GIỮA BIỂU HIỆN CÁC GEN SUMO1, SUMO2, SUMO3 TRONG MÔ U GAN VỚI MỘT SỐ ĐẶC ĐIỂM KHỐI U Ở BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAN CÓ HBSAG (+)

Abstract

Objective: To investigate the expression levels of SUMO1, SUMO2, SUMO3 genes in tumor tissues and their association with clinicopathological characteristics in HBsAg-positive hepatocellular carcinoma (HCC) patients. Subjects and methods: In this cross-sectional study, 69 paired tumor and adjacent non-tumorous tissues were collected from HBsAg-positive HCC patients who underwent surgical resection from July 2022 to July 2024. The relative mRNA expression of SUMO1, SUMO2, and SUMO3 was quantified using Real-time PCR. Results: The average relative expression levels of SUMO1, SUMO2 and SUMO3 genes in cancer tissue were all higher than the reference genes (average (-∆Ct) were: 2,00; 3,74; 1,32, respectively). The expression of SUMO2 gene had a statistically significant difference in cancer tissue samples compared to adjacent tumor tissue samples (p < 0,0001). There was no correlation between the relative expression levels of SUMO1, SUMO2 and SUMO3 genes in cancer tissue and some characteristics of the tumor (size, number, portal vein thrombosis) and pathology (structure, intratumoral vascular invasion, cirrhosis). Conclusion: SUMO2 gene was increased in tumor tissue compared to adjacent tumor tissue. There was no correlation between the relative expression levels of SUMO1, SUMO2 and SUMO3 genes in cancer tissue and some characteristics of the tumor and pathology.