XÁC ĐỊNH YẾU TỐ ẢNH HƯỞNG ĐẾN ĐÁP ỨNG ĐIỀU TRỊ VỚI LIỆU PHÁP NHĨ HOÀN KẾT HỢP BÀI THUỐC TIÊU PHONG TÁN TRÊN NGƯỜI BỆNH VIÊM DA CƠ ĐỊA MỨC ĐỘ NHẸ ĐẾN TRUNG BÌNH

Abstract

Objective: To identify factors influencing treatment response with auricular acupuncture (AA) combined with Xiao-Feng-San in patients with atopic dermatitis (AD). Methods: This was a secondary analysis of data from a 4-week randomized controlled clinical trial. Patients with non-severe AD and a wind-damp-heat syndrome pattern were treated with Xiao-Feng-San and randomly assigned to the AA group (n=78) or sham AA group (n=78). Independent predictors were estimated using multivariable logistic regression; models also included interactions between treatment group and baseline characteristics to assess potential effect modification. Results: Treatment group and disease stage were significant factors affecting response. AA was associated with higher response compared with sham (OR=20.55; p<0.0001), while the chronic stage was associated with lower response compared with the acute stage (OR=0.11; p=0.043). No evidence was found that the effect of AA was influenced by disease severity, baseline IgE, or disease duration. Conclusion: Intervention type and disease stage were independent factors affecting treatment response. AA produced better responses, whereas the chronic stage predicted poorer outcomes. The benefit of AA was consistent across different baseline characteristics, supporting its broader application, particularly in the early stage of the disease