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Date Published: 08/01/2022
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DOI: https://doi.org/10.51298/vmj.v508i2.1609
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Vol. 508 No. 2 (2021)
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Các bài báo
How to Cite
Thị Anh Đào, L. ., & Thị Hằng, N. . (2022). CLINICAL FEATURES OF UNEXPLAINED RECURRENT PREGNANCY LOSS WOMEN CARRYING ABNORMAL MTHFR POLYMORPHISM GENE. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1609

CLINICAL FEATURES OF UNEXPLAINED RECURRENT PREGNANCY LOSS WOMEN CARRYING ABNORMAL MTHFR POLYMORPHISM GENE

Lê Thị Anh Đào1,, Nguyễn Thị Hằng2
1 Hanoi Medical University
2 Vinmec Times City International Hospital

Main Article Content

Abstract

Unexplained RPL has been a challenging issue in diagnosis. Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T, A1298C) are believed to be risk of unexplained recurrent pregnancy loss. This study aims to describe the clinical signs of women with recurrent pregnancy loss and MTHFR polymorphism gene. This is a case-control study was performed on 2 groups. Both two groups were evaluated for the presence of MTHFR gene polymorphisms by PCR technique. Result: A total of 43 cases and 30 controls were identified. The gene carrying group had earlier miscarriage time in the history 8.47 weeks. MTHFR C677T polymorphism gene was increased the risk of miscarriage symptoms in the first trimester (abdominal pain: OR=5.6, 95%CI: 1.1-28.6, p=0.038, vaginal bleeding: OR=3.6, 95%CI: 1.0-12.5, p=0.043). Conclusion: MTHFR C677T gene polymorphism is associated with increased risk of URPL in Vietnamese women and miscarriage symptoms in the first trimester.

Article Details

Keywords

MTHFR C677T, MTHFR A1298C, polymorphism, Unexplained recurrent pregnancy loss

References

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