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Date Published: 08/01/2022
Abstract Views: 132
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DOI: https://doi.org/10.51298/vmj.v508i2.1610
Issue
Vol. 508 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Tịnh, M. ., Trọng Tuệ, N. ., Cẩm Tú, H. ., Hoàng Việt, N. ., & Thu Thúy, N. . (2022). SINGLE NUCLEOTIDE POLYMORPHISM RS2856718 IN HLA-DQ GENE ON HEPATOCELLULAR CARCINOMA PATIENTS. Vietnam Medical Journal, 508(2). https://doi.org/10.51298/vmj.v508i2.1610

SINGLE NUCLEOTIDE POLYMORPHISM RS2856718 IN HLA-DQ GENE ON HEPATOCELLULAR CARCINOMA PATIENTS

Mạc Thị Tịnh1,2, Nguyễn Trọng Tuệ1, Hồ Cẩm Tú1, Nguyễn Hoàng Việt1, Nguyễn Thu Thúy1,
1 Center for Gene - Protein Research, Hanoi Medical University
2 Haiphong University of Medicine and Pharmacy

Main Article Content

Abstract

Primary liver cancer is a common cancer with a high mortality rate. The HLA-DQ gene encodes polypeptide chains of MHC class II molecules involved in the activation of antigen-presenting cells in the immune response. The single nucleotide polymorphism (SNP) rs2856718 of HLA-DQ gene may be associated with chronic hepatitis B virus infection and hepatocellular carcinoma (HCC). This study was aimed to determine the distribution of SNP rs2856718, and to evaluate the association between this SNP and the risk of HCC. RT-PCR technique was used to genotype SNP rs2856718 in 93 HCC patients and 93 healthy individuals. The results determined that the rate of GG, AG, and AA genotypes was 39.8%, 46.2%, 14% for the HCC group and 30.1%, 53.8%, 16.1% for the control group, respectively. No association was found between SNP rs2856718 with the risk of HCC and other risk factors.

Article Details

Keywords

SNP, rs2856718, HLA-DQ, hepatocellular carcinoma

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