CLINICAL FEATURES AND LABORATORY ABNORMALITIES OF SOME COMMON NEUROLEPTIC POISONINGS

Lưu Văn Hậu1,, Đặng Thị Xuân2
1 Hanoi Medical University
2 Poison Control Center

Main Article Content

Abstract

Objectives: to describe the clinical characteristics and laboratory features of patients with acute poisoning of some common neuroleptics at Vietnam Poison Control Center, Bach Mai Hospital. Methods: A prospective observational study included 61 patients poisoned by some common neuroleptics from January 2020 to October 2021. Results: Among the study patients, female accounted for 55.7%, the mean age was 38.9 ± 18.6 (15-81) years old, the most common cause of poisoning was suicide (88.5%). 68.8% of the patients were poisoned with atypical neuroleptics, more common than typical group (26.2%). Most of the patients were hospitalized with mild symptoms (77.1%), common clinical symptoms include unconsciousness (37.7%), tachycardia (42.6%), respiratory failure (23). %) and pupil constriction (16.4%). Common electrocardiographic changes included sinus tachycardia and QTc prolongation. Conclusion: The study revealed the main clinical and laboratory characteristics of patients with acute poisoning of some common neuroleptics.

Article Details

References

1. Boushra M, Nagalli S. Neuroleptic Agent Toxicity. In: StatPearls. ; 2020.
2. DeSilva P, Fenton M, Rathbone J. Zotepine for schizophrenia. Cochrane Database Syst Rev. 2006; (4): CD001948. doi:10.1002/ 14651858.CD001948.pub2
3. Minns AB, Clark RF. Toxicology and overdose of atypical antipsychotics. J Emerg Med. 2012;43(5):906-913. doi:10.1016/j.jemermed.2012.03.002
4. Journal of Basic and Clinical Health Sciences » Makale » Antipsychotic Exposures in an Emergency Department. Accessed October 31, 2021. https://dergipark.org.tr/tr/pub/jbachs/issue/58467/844615
5. Mubarak M, El Madah E, El Gharbawy D, Ashmawy M. Assessment of Acute Antipsychotic Poisoned Cases Admitted to Tanta University Poison Control Unit. Ain Shams Journal of Forensic Medicine and Clinical Toxicology. 2019;33(2):113-125. doi:10.21608/ajfm.2019.43103
6. Tan HH, Hoppe J, Heard K. A systematic review of cardiovascular effects after atypical antipsychotic medication overdose. Am J Emerg Med. 2009; 27(5):607-616. doi:10.1016/ j.ajem.2008.04.020