ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA BỆNH NHÂN VIÊM RUỘT MẠN CÓ NHIỄM KHUẨN

Abstract

Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, with a rising prevalence in developing countries. Infection represents a major determinant of increased hospitalization and suboptimal therapeutic outcomes in IBD. We conducted a cross-sectional study involving 62 infected and 169 non-infected patients at Hanoi Medical University Hospital and Bach Mai Hospital. The cohort was predominantly male (55%), with 10,4% aged over 65 years, and a mean hospital stay of 14,5 ± 8,2 days. The most common gastrointestinal infection in both Crohn’s disease and ulcerative colitis was observed at rates of 22,5% and 26,1%, respectively, with the predominant clinical manifestations being fever (100%) and abdominal pain (71%). Infection was most frequent in severe disease (33,3%) and strongly associated with TNF-α inhibitors or combination therapy. Infected patients showed elevated leukocyte count, ESR, hs-CRP, and PCT compared with non-infected cases.