HIỆU QUẢ ĐIỀU TRỊ LOÉT TÁ TRÀNG CÓ NHIỄM HELICOBACTER PYLORI Ở TRẺ EM BẰNG PHÁC ĐỒ 4 THUỐC CÓ BISMUTH TẠI BỆNH VIỆN NHI THÁI BÌNH

Abstract

Duodenal ulcer is a deep lesion characterized by loss of tissue in the acid and pepsin-secreting digestive tract mucosa, extending through the muscularis mucosa. The disease is characterized by chronicity and frequent recurrence. Aims: To evaluate the efficacy of a bismuth-containing quadruple therapy regimen for treating H. pylori-infected peptic ulcers in children at Thai Binh Pediatric Hospital. Materials and Methods: A prospective descriptive study was conducted on 42 pediatric patients (3–16 years old) diagnosed with H. pylori-infected duodenal ulcers using a rapid urease test and histopathology. The children were treated with bismuth-containing quadruple therapy. Efficacy was assessed by H. pylori eradication rate, ulcer healing, symptom improvement, and side effects. Results: The mean age was 11.5 ± 2.1 years; male/female ratio was 2.5/1. After 6 weeks of treatment, H. pylori eradication was 81%, ulcer healing 88.1 %. 11.9% had not healed and required additional treatment. 78.6% of patients had resolution of abdominal pain symptoms. The only adverse effect observed was fatigue, with a low incidence, not requiring discontinuation of treatment. Conclusion: The bismuth-containing quadruple therapy regimen demonstrated high efficacy in H. pylori eradication and healing of peptic ulcers in children, was safe and well-tolerated, and is suitable for implementation in Thai Binh.