TỶ SỐ ALBUMIN/CREATININE NIỆU Ở NGƯỜI BỆNH ĐÁI THÁO ĐƯỜNG TYPE 2 TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI 2025

Abstract

Objective: To investigate the urinary albumin-to-creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) at Hanoi Medical University Hospital and to explore factors associated with UACR in this patient group. Subjects: A total of 243 patients diagnosed with T2DM who attended for examination and treatment at Hanoi Medical University Hospital. Methods: A cross-sectional descriptive study. Results: Among 243 T2DM patients tested, 21.4% had a positive UACR, including 18.5% with positive microalbuminuria (MAU) and 2.9% with positive macroalbuminuria (MAC). Age (ρ = 0.217; p = 0.001), duration of diabetes (ρ = 0.214; p = 0.001), systolic blood pressure (SBP) (ρ = 0.256; p = 0.000), diastolic blood pressure (DBP) (ρ = 0.217; p = 0.001), fasting plasma glucose (ρ = 0.178; p = 0.005), HbA1c (ρ = 0.258; p = 0.000), and triglycerides (ρ = 0.156; p = 0.015) were all positively correlated with UACR, with statistical significance (p < 0.05). Patients aged ≥ 60 years had a 2.166-fold higher risk of positive UACR compared with those aged < 60 years (OR = 2.166; p = 0.015). Additionally, patients with estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m² had a 2.794-fold higher risk of positive UACR compared with those with eGFR ≥ 60 ml/min/1.73 m² (OR = 2.794; p = 0.017). Both differences were statistically significant (p < 0.05). Conclusion: Our study showed that 21.4% of T2DM patients had a positive UACR. Among the variables positively correlated with UACR, HbA1c and SBP exhibited the strongest correlations (ρ = 0.258 and 0.256, respectively), highlighting poor glycemic control and elevated blood pressure as key risk factors for increased UACR. Moreover, patients aged ≥ 60 years and those with eGFR < 60 ml/min/1.73 m² were at significantly higher risk (2.166-fold and 2.794-fold, respectively) of positive UACR, suggesting that advanced age and impaired renal function are important determinants of early kidney damage in T2DM patients.