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ASSOCIATION BETWEEN BLASTOCYSTIS SP INFECTION AND PARACLINICAL PARAMETERS IN PATIENTS WITH COLITIS
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Abstract
Background: The pathogenesis of Blastocystis sp. remains unclear. Some studies have shown that the presence of B.hominis is associated with clinical symptoms such as acute or chronic diarrhea, abdominal pain, anorexia, flatulence, nausea, and vomiting, as well as decreased hemoglobin (Hb) levels and serum iron. The aim of this study was to comprehensively evaluate the prevalence of Blastocystis sp. infection, associated symptoms, and some indices of complete blood count in patients with colitis. Method: A cross-sectional study was conducted on 128 patients with colitis and 132 individuals with other pathologies, aged 18 and over, who had indications for fresh stool examination, at the University Medical Center HCMC, Ho Chi Minh City, Vietnam, from January to October 2024. Results: There were no significant differences in the distribution of demographic characteristics between the colitis group and the other disease groups. Male sex, age over 60 years, and normal BMI were the predominant characteristics in both groups. The prevalence of Blastocystis infection in the colitis group was 14.1%. Statistically significant differences were found in LYM% (p = 0.02), MONO% (p = 0.003), and RBC (p = 0.04) between colitis patients with B.hominis infection and those without. Conclusion: The study showed an association between Blastocystis sp. and certain hematological indices, as well as abdominal pain symptoms in patients with colitis, although the infection rate was not higher than in other disease groups. Further in-depth studies using more sensitive detection methods and better control of confounding factors are needed to clarify the role of Blastocystis in the pathogenesis of colitis
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Keywords
Blastocystis, paraclinical parameters, colitis
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